Introduction Obesity is a worldwide public health problem. Experimental animal and in vitro studies suggest that the exposure to BPA and phthalates are associated to a higher risk of obesity. Objective To determine urinary excretion of bisphenol A and phthalates in obese and normal weight children. Methods A case-control study was conducted in 122 children. Sixty-six obese children 36 girls (mean age 8.41±1.27 years) and 30 boys (mean age 8.51 ± 1.33 years), and 56 normal weight children, 27 girls (mean age 7.64 ± 1.49 years) and 29 boys (mean age 7.77 ± 1.56 years) were studied. Urinary BPA and Bis(2-ethylhexyl) phthalate (DEHP) metabolites (MEHP, MEHHP and MEOHP) were measured respectively by gas chromatography and high-performance liquid chromatography. Individual determinants of exposure were evaluated through "ad hoc" questionnaires. Results BPA and DEHP metabolites were detectable in obese and normal weight children. Obese girls showed significantly higher BPA concentrations in comparison with normal weight girls (means 10.77, 95% CI 7.02-16.53 vs 5.50, 95% CI 3.93-7.71 µg/g creatinine, respectively, p< 0.02). The first step of DEHP metabolic rate was significantly higher in obese girls compared with controls (p<0.05). DEHP metabolites correlated significantly with leptin concentrations in obese girls (p< 0.03). A higher risk of obesity was found in children with BPA levels above the median values with the habit to eat food packaged (OR=11.09, 95% CI=1.28-95.78). Conclusions These findings show that a higher exposure to BPA is associated with the risk of obesity in girls. Further studies are needed to unveil the cause-effect relationship.

中文翻译：

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肥胖儿童尿液中双酚 A (BPA) 和邻苯二甲酸双(2-乙基己基)酯 (DEHP) 代谢物浓度：一项病例对照研究。

简介 肥胖是一个世界性的公共卫生问题。实验动物和体外研究表明，接触 BPA 和邻苯二甲酸盐与肥胖风险较高有关。目的测定肥胖儿童和正常体重儿童尿中双酚A和邻苯二甲酸盐的排泄量。方法对122名儿童进行病例对照研究。66 名肥胖儿童，其中 36 名女孩（平均年龄 8.41±1.27 岁）和 30 名男孩（平均年龄 8.51 ± 1.33 岁），以及 56 名正常体重儿童，27 名女孩（平均年龄 7.64 ± 1.49 岁）和 29 名男孩（平均年龄 7.77 岁） ± 1.56 年）进行了研究。分别采用气相色谱法和高效液相色谱法测定尿液中的 BPA 和邻苯二甲酸二（2-乙基己基）酯 (DEHP) 代谢物（MEHP、MEHHP 和 MEOHP）。通过“特别”调查问卷评估暴露的个体决定因素。结果在肥胖和正常体重儿童中均可检测到 BPA 和 DEHP 代谢物。与正常体重女孩相比，肥胖女孩的 BPA 浓度显着较高（平均 10.77，95% CI 7.02-16.53 vs 5.50，95% CI 3.93-7.71 µg/g 肌酐，p < 0.02）。与对照组相比，肥胖女孩的 DEHP 第一步代谢率显着较高（p<0.05）。DEHP 代谢物与肥胖女孩的瘦素浓度显着相关 (p<0.03)。BPA 水平高于中位值且习惯吃包装食品的儿童肥胖风险较高（OR=11.09，95% CI=1.28-95.78）。结论 这些发现表明，较高的 BPA 暴露与女孩肥胖的风险相关。需要进一步的研究来揭示因果关系。