Background: Social exposures are linked to an array of health outcomes, especially around aging. In this study, we examined the association of social capital, defined as social relationships and networks, with clinical and biological outcomes including cognitive health, oral inflammation, and epigenetic aging. Methods: We used data from the Canadian Longitudinal Study on Aging (CLSA) (n = 1,479; aged 45-85 years), categorizing social capital as structural and cognitive capital. Oral inflammation was determined as the presence of gum bleeding. Epigenetic aging was computed as the difference between chronological age and DNA methylation age. We constructed multivariable regression models adjusted for covariates to assess the relationships of interest. Results: Higher structural social capital was associated with decelerated epigenetic aging and better cognitive health outcomes, while higher cognitive social capital was associated with better cognitive outcomes and less oral inflammation. Conclusion: Enhanced social capital may contribute to better clinical and biological outcomes around aging.

中文翻译：

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社会资本与更好的认知健康、口腔健康和表观遗传年龄减缓相关：加拿大老龄化纵向研究的结果。

背景：社会暴露与一系列健康结果相关，尤其是与衰老相关的健康结果。在这项研究中，我们研究了社会资本（定义为社会关系和网络）与临床和生物学结果（包括认知健康、口腔炎症和表观遗传衰老）之间的关联。方法：我们使用加拿大老龄化纵向研究 (CLSA) 的数据（n = 1,479；年龄 45-85 岁），将社会资本分类为结构资本和认知资本。口腔炎症被确定为牙龈出血的存在。表观遗传衰老计算为实际年龄和 DNA 甲基化年龄之间的差异。我们构建了针对协变量进行调整的多变量回归模型，以评估感兴趣的关系。结果：较高的结构性社会资本与减缓表观遗传衰老和更好的认知健康结果相关，而较高的认知社会资本与更好的认知结果和更少的口腔炎症相关。结论：增强的社会资本可能有助于改善衰老相关的临床和生物学结果。