OBJECTIVE A prospective experiment was designed to explore all possible SNPs in the promoter region of fibrinogen B β (FGB) and reveal the influence of these SNPs on susceptibility of pulmonary embolism. METHODS In this 2-year randomized prospective study, we had totally recruited 203 volunteers. 58 PE patients (58 out of 145 VTE patients) and 114 healthy people were taken as case and control objects, respectively. FGB promoter was detected by gene sequencing. RESULTS There were 6 SNPs in FGB promoter, which were β-1420G/A, β-993C/T, β-854G/A, β-455G/A, β-249C/T, and β-148C/T. Genotype frequencies of individual SNPs between the cases and controls were not statistically significant, all p > .05. After excluding subjects of COVID-19 infection within 6 months, the statistical results (35 PE patients vs 66 healthy people) were consistent. CONCLUSION The susceptibility to pulmonary embolism may not be affected by any SNP in the FGB promoter region.

中文翻译：

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纤维蛋白原 B β 启动子多态性可能与肺栓塞无关。

目的 设计前瞻性实验，探讨纤维蛋白原Bβ（FGB）启动子区所有可能的SNP，揭示这些SNP对肺栓塞易感性的影响。方法在这项为期2年的随机前瞻性研究中，我们总共招募了203名志愿者。分别选取58名PE患者（145名VTE患者中的58名）和114名健康人作为病例和对照对象。通过基因测序检测FGB启动子。结果 FGB启动子区共有6个SNP，分别为β-1420G/A、β-993C/T、β-854G/A、β-455G/A、β-249C/T、β-148C/T。病例和对照之间单个 SNP 的基因型频率没有统计学意义，全部 p > 0.05。排除6个月内感染过COVID-19的受试者后，统计结果（35名PE患者与66名健康人）是一致的。结论 FGB启动子区的SNP可能不会影响肺栓塞的易感性。