当前位置：
X-MOL 学术
›
Cerebrovasc. Dis.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association between Fibrinogen-to-Albumin Ratio and Adverse Stroke Outcomes among Patients with Acute Ischemic Stroke.
Cerebrovascular Diseases ( IF 2.9 ) Pub Date : 2023-11-20 , DOI: 10.1159/000535303 Xiaoyu Wang , Yuesong Pan , Runhua Zhang , Mengxing Wang , Haiqiang Qin , Xia Meng , Zixiao Li , Hao Li , Yilong Wang , Xingquan Zhao , Yongjun Wang , Gaifen Liu
Cerebrovascular Diseases ( IF 2.9 ) Pub Date : 2023-11-20 , DOI: 10.1159/000535303 Xiaoyu Wang , Yuesong Pan , Runhua Zhang , Mengxing Wang , Haiqiang Qin , Xia Meng , Zixiao Li , Hao Li , Yilong Wang , Xingquan Zhao , Yongjun Wang , Gaifen Liu
INTRODUCTION
Fibrinogen-to-albumin ratio (FAR) is implicated in prothrombotic states and is associated with an increased risk of acute ischemic stroke (AIS). However, studies investigating whether the prothrombotic effect of FAR is associated with long-term adverse outcomes in patients with AIS are lacking. Therefore, we aimed to investigate the association based on The Third China National Stroke Registry (CNSR-III).
METHODS
Patients with AIS with complete laboratory data for fibrinogen and albumin in the CNRS-III were included in this study. The primary outcomes were poor functional outcomes (modified Rankin scale score 3-6) at 12 months, including disability (modified Rankin scale score 3-5), all-cause death, recurrent stroke, and combined vascular events within 1 year. Univariate and multivariate logistic or Cox regression analyses were used to investigate the association between FAR quartiles and adverse outcomes.
RESULTS
A total of 8984 patients with AIS were enrolled in this study. After one-year follow-up, 238 patients were lost to follow-up. A total of 1230(14.06%) patients had poor functional outcomes; 932(10.37%) and 981(10.92%) experienced stroke recurrence and combined vascular events, respectively. The adjusted odds ratios/hazard ratios and 95% confidence intervals of the highest quartile of the FAR(>11.44) were 1.64(1.35-2.00) for poor functional outcomes, 1.68(1.34-2.10) for disability, 1.40(1.02-1.94) for all-cause death, 1.11(0.92-1.34) for stroke recurrence, and 1.11(0.92-1.33) for combined vascular event, respectively.
CONCLUSION
High FAR(>11.44) increased the risk of short- and long-term poor functional outcomes, including disability and all-cause death among patients with AIS. The FAR may play an important role in the early stratification of patients with AIS.
更新日期：2023-11-20
京公网安备 11010802027423号