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Identification and molecular characterization of two papillomavirus genotypes in teat papillomatosis cases in hair goats, in Türkiye
Comparative Immunology, Microbiology and Infectious Diseases ( IF 2 ) Pub Date : 2023-12-04 , DOI: 10.1016/j.cimid.2023.102111
Yakup Yıldırım , Fırat Doğan , Gökhan Bozkurt , Ali Küçük , Gülizar Acar , Seval Bilge-Dağalp

Papillomaviruses can cause benign or malignant proliferations on the host’s skin and mucous membranes. Recent genetic studies have identified many new papillomavirus types. In this study, molecular detection and typing was performed on papilloma samples from eight hair goats with teat papillomatosis. The papilloma samples were tested with degenerate (FAP59/FAP64,MY09/MY11) and type-specific primers. One sample was positive with degenerate (MY09/MY11) and two samples were positive with Caprahircus papillomavirus-1 type specific primers. The MY09/MY11 primer sequence indicated identity to the closest Ovine papillomavirus type-2 (77.9%). The ChPV-1 primer sequence was similar to the closest ChPV-1 (99.4%). Investigating papillomavirus types in different animal species is important for determining the evolution, prevalence, host range, and interspecies transmission potential of papillomaviruses, and to indicate suitable therapeutics for later development.



中文翻译:


土耳其毛山羊乳头乳头状瘤病病例中两种乳头瘤病毒基因型的鉴定和分子特征



乳头瘤病毒可引起宿主皮肤和粘膜良性或恶性增殖。最近的遗传学研究发现了许多新的乳头瘤病毒类型。在这项研究中,对八只患有乳头乳头状瘤病的毛山羊的乳头状瘤样本进行了分子检测和分型。使用简并(FAP59/FAP64、MY09/MY11)和类型特异性引物测试乳头状瘤样品。一份样本呈简并 (MY09/MY11) 阳性,两份样本呈山羊乳头瘤病毒 1 型特异性引物阳性。 MY09/MY11 引物序列表明与最接近的羊乳头瘤病毒 2 型具有同一性 (77.9%)。 ChPV-1 引物序列与最接近的 ChPV-1 相似 (99.4%)。研究不同动物物种中的乳头瘤病毒类型对于确定乳头瘤病毒的进化、流行、宿主范围和种间传播潜力以及为后续开发指明合适的治疗方法非常重要。

更新日期:2023-12-04
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