Diabetic foot infections are one of the complications of diabetes mellitus resulting in extremity amputation and mortality. This study aimed to examine the predictive value of the C-reactive protein (CRP) to albumin ratio (CAR) for amputation risk in diabetic foot infection. Data from 178 patients were retrospectively examined. We found the cut point value of 15.45 according to the receiver operating characteristic (ROC) curve to show the predictive value of CAR for amputation risk in the overall population. We then divided the patients into two groups low (<15.45, n = 96) and high risk (≥15.45, n = 82) according to their CAR value. Matching based on propensity scores produced 64 patients in each group and showed that the amputation rate was high in the high-risk groups (50 vs 25%, P = .003). In the multivariate analysis in the matching group, previous amputation, antibiotic therapy in the last 3 months, and CAR (Odds ratio [OR]: 1.30, 95%Confidence interval [CI]: 1.01-1.45, P < .001) were independent predictors of amputation. These parameters may be useful to predict amputation risk in these patient groups.

中文翻译：

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C 反应蛋白与白蛋白比率对糖尿病足感染截肢风险的预测价值。

糖尿病足感染是糖尿病的并发症之一，导致截肢和死亡。本研究旨在探讨 C 反应蛋白 (CRP) 与白蛋白比率 (CAR) 对糖尿病足感染截肢风险的预测价值。对 178 名患者的数据进行了回顾性检查。我们根据受试者工作特征（ROC）曲线找到切点值15.45，以显示CAR对总体人群截肢风险的预测价值。然后，我们根据 CAR 值将患者分为低风险组（<15.45，n = 96）和高风险组（≥15.45，n = 82）。基于倾向评分的匹配在每组中产生了 64 名患者，结果显示高风险组的截肢率较高（50% vs 25%，P = .003）。在匹配组的多变量分析中，既往截肢、最近 3 个月的抗生素治疗和 CAR（比值比 [OR]：1.30，95% 置信区间 [CI]：1.01-1.45，P < .001）是独立的截肢的预测因子。这些参数可能有助于预测这些患者组的截肢风险。