Nonylphenol (NP) is potent noxious pollutant which is documented to induce nephrotoxicity via escalating the levels of oxidative stress in renal tissues. Aucubin (AUC) is a novel phytochemical having tremendous pharmacological abilities. This research aimed to estimate the efficacy of AUC against NP intoxicated renal impairment in male albino rats. 48 albino rats were randomly assigned into four different groups viz. control group, NP administered group (50mg/kg), NP+AUC administrated (50mg/kg + 40mg/kg) group and AUC treated (40mg/kg) group. Our results showed that NP intoxication raised urinary proteins, creatinine, urea, urobilinogen, NGAL and KIM-1 levels. Besides, NP exposure lowered the levels of creatinine clearance and albumin. Furthermore, NP treatment lowered level of total protein, activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GSR) & glutathione (GSH) contents along with the level of total antioxidant status (TAS) however, raising the oxidative stress markers levels Thiobarbituric acid reactive substance (TBARS), reactive oxygen species (ROS), hydrogen peroxide (H₂O₂) & total oxidant status (TOS). Additionally, following the NP administration, the levels of Bax, caspase-9, & caspase-3 were augmented however the Bcl-2 level was decreased. Furthermore, rats exposed to NP showed various histopathological disruptions. Whereas treatment with AUC showed a palliative effect against NP-induced renal damage, restoring all alterations to normal levels. Taken together, AUC administration convalesced NP-induced kidney impairment.

壬基酚 (NP) 是一种强效有毒污染物，据记录可通过增加肾组织中的氧化应激水平来诱导肾毒性。Aucubin (AUC) 是一种具有巨大药理能力的新型植物化学物质。本研究旨在评估 AUC 对雄性白化大鼠 NP 中毒肾损伤的疗效。48只白化大鼠被随机分为四个不同组，即。对照组、NP给药组(50mg/kg)、NP+AUC给药(50mg/kg+40mg/kg)组和AUC治疗组(40mg/kg)。我们的结果表明，NP 中毒会升高尿蛋白、肌酐、尿素、尿胆素原、NGAL 和 KIM-1 水平。此外，NP暴露降低了肌酐清除率和白蛋白的水平。此外，NP处理降低了总蛋白水平、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽S-转移酶（GST）、谷胱甘肽还原酶（GSR）和谷胱甘肽（GSH）含量以及然而，总抗氧化状态（TAS）的水平提高了氧化应激标志物硫代巴比妥酸反应物质（TBARS）、活性氧（ROS）、过氧化氢（H ₂ O ₂）和总氧化状态（TOS）的水平。此外，施用 NP 后，Bax、caspase-9 和 caspase-3 的水平升高，但 Bcl-2 水平降低。此外，暴露于 NP 的大鼠表现出各种组织病理学破坏。而 AUC 治疗显示出对 NP 引起的肾损伤的姑息作用，使所有改变恢复到正常水平。总而言之，AUC 给药可恢复 NP 诱导的肾损伤。