Objective: Severe neurosurgical central nervous system infections (sNCNSIs) are among the most serious complications of neurosurgical disease. Conventional methods have shown a poor prognosis. This study aims to analyze the clinical characteristics of vacuum-assisted closure (VAC) in sNCNSIs with the help of antibiotic irrigation treatment. Patients and Methods: A retrospective study was performed for patients diagnosed with sNCNSIs. A VAC device was placed on the incision after debridement and the surgical cavity was rinsed with antibiotic agents in the VAC group. Meanwhile the surgical cavity was drained after debridement in the control group. Medical data were reviewed and analyzed. Results: Twenty-eight patients met the inclusion criteria, including 18 cases in the VAC group and 10 cases in the control group. The basic medical data showed no differences. Bacteria was isolated from 24 (85.7%) patients. The cure rate was significantly higher in the VAC group (p < 0.05). The cure rate in patients with multi-drug-resistant (MDR) infections was significantly higher in patients treated with VAC therapy (p < 0.05). The prognosis evaluated by Glasgow Outcome Score (GOS) between the two groups showed significant difference (p < 0.05). No re-infection in the VAC group occurred in the follow-up period. Conclusions: It is suggested that VAC-assisted antibiotic irrigation is safe and effective for patients with severe NCNSIs and can improve the prognosis dramatically. The results can provide a new effective and reasonable therapeutic strategy for patients with sNCNSIs.

中文翻译：

---

真空辅助闭合辅助抗生素冲洗治疗严重神经外科中枢神经系统感染的分析。

目的：严重的神经外科中枢神经系统感染（sNCNSI）是神经外科疾病最严重的并发症之一。传统方法的预后较差。本研究旨在分析 sNCNSI 借助抗生素冲洗治疗进行真空辅助封堵术 (VAC) 的临床特征。患者和方法：对诊断为 sNCNSI 的患者进行了一项回顾性研究。VAC组清创后在切口上放置VAC装置，并用抗生素冲洗手术腔。同时对照组清创后术腔引流。对医疗数据进行了审查和分析。结果：28例患者符合纳入标准，其中VAC组18例，对照组10例。基本医疗数据无差异。从 24 名 (85.7%) 患者身上分离出细菌。VAC 组的治愈率显着较高 (p < 0.05)。接受 VAC 治疗的多重耐药 (MDR) 感染患者的治愈率显着更高 (p < 0.05)。两组间格拉斯哥预后评分（GOS）评估的预后差异有显着性（p < 0.05）。VAC组随访期间未出现再感染情况。结论：VAC 辅助抗生素冲洗对于严重 NCNSI 患者安全有效，可显着改善预后。研究结果可为sNCNSI患者提供新的有效合理的治疗策略。