Spinal cord injury (SCI) is a serious nervous system disease that usually leads to the impairment of the motor, sensory, and autonomic nervous functions of the spinal cord, and it places a heavy burden on families and healthcare systems every year. Due to the complex pathophysiological mechanism of SCI and the poor ability of neurons to regenerate, the current treatment scheme has very limited effects on the recovery of spinal cord function. In addition, due to their unique advantages, exosomes can be used as carriers for cargo transport. In recent years, some studies have confirmed that treatment with mesenchymal stem cells (MSCs) can promote the recovery of SCI nerve function. The therapeutic effect of MSCs is mainly related to exosomes secreted by MSCs, and exosomes may have great potential in SCI therapy. In this review, we summarized the repair mechanism of mesenchymal stem cells-derived exosomes (MSCs-Exos) in SCI treatment and discussed the microRNAs related to SCI treatment based on MSCs-Exos and their mechanism of action, which is helpful to further understand the role of exosomes in SCI.

中文翻译：

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间充质干细胞外泌体在脊髓损伤中的作用：系统评价。

脊髓损伤（SCI）是一种严重的神经系统疾病，通常会导致脊髓的运动、感觉和自主神经功能受损，每年给家庭和医疗系统带来沉重的负担。由于SCI病理生理机制复杂，神经元再生能力差，目前的治疗方案对脊髓功能的恢复效果非常有限。此外，由于其独特的优势，外泌体可以作为货物运输的载体。近年来，一些研究证实间充质干细胞（MSCs）治疗可以促进SCI神经功能的恢复。MSCs的治疗效果主要与MSCs分泌的外泌体有关，外泌体在SCI治疗中可能具有巨大的潜力。本文综述了间充质干细胞源性外泌体（MSCs-Exos）在SCI治疗中的修复机制，并讨论了基于MSCs-Exos的与SCI治疗相关的microRNA及其作用机制，有助于进一步了解SCI治疗中的相关microRNA及其作用机制。外泌体在 SCI 中的作用。