Background Peptic ulcer disease has been a major threat to the world's population, which remains a significant cause of hospitalization worldwide and healthcare resource utilization. Objectives We aimed to describe the global burden, trends, and inequalities of peptic ulcer disease. Design An observational study was conducted. Methods In this secondary analysis of the Global Burden of Disease, Injuries, and Risk Factors Study 2019, we extracted data for age-standardized incidence rates (ASIRs), disability-adjusted life year rates (ASDRs), and mortality rates (ASMRs); then, we stratified by age, level of regionals, and country; subsequently, we calculated estimated annual percentage changes (EAPC) of ASIR, ASDR, ASMR, and quantified cross-country inequalities in peptic ulcer disease mortality. Results Globally, ASIR showed a continuous downward trend, from 63.84 in 1990 to 44.26 per 100,000 population in 2019, with an annual decrease of 1.42% [EAPC = -1.42 (95% CI: -1.55 to -1.29)]. ASDR showed a continuing downward trend, and the EAPC was -3.47% (-3.58 to -3.37). ASMR showed a persistent decline, declining by nearly half in 2019 compared to 1990 (3.0 versus 7.39 per 100,000 population), with an annual decrease of 2.55% [EAPC = -3.36 (95% CI: -3.47 to -3.25)]. A significant reduction in sociodemographic index (SDI)-related inequality, from an excess of 190.43 disability-adjusted life years (DALY) per 100,000 (95% CI: -190.83 to -190.02) between the poorest and richest countries in 1990 to 62.85 DALY per 100,000 (95% CI -62.81 to -62.35) in 2019. Conclusion Global peptic ulcer disease morbidity and mortality rates decreased significantly from 1990 to 2019. These health gains were in accordance with a substantial reduction in the magnitude of SDI-related inequalities across countries, which is paired with overall socioeconomic and health improvements observed in the region.

中文翻译：

---

1990-2019 年 204 个国家和地区的消化性溃疡疾病负担、趋势和不平等：一项基于人群的研究。

背景消化性溃疡病一直是世界人口的主要威胁，仍然是全世界住院和医疗资源利用的重要原因。目标 我们旨在描述消化性溃疡病的全球负担、趋势和不平等。设计 进行了一项观察性研究。方法 在 2019 年全球疾病负担、伤害和风险因素研究的二次分析中，我们提取了年龄标准化发病率 (ASIR)、伤残调整生命年率 (ASDR) 和死亡率 (ASMR) 的数据；然后，我们按照年龄、地区级别和国家进行分层；随后，我们计算了 ASIR、ASDR、ASMR 的估计年度百分比变化 (EAPC)，并量化了消化性溃疡病死亡率的跨国不平等。结果 全球范围内，ASIR 呈持续下降趋势，从 1990 年的每 10 万人口 63.84 下降到 2019 年的每 10 万人口 44.26，年下降 1.42%[EAPC = -1.42（95% CI：-1.55 至 -1.29）]。ASDR呈现持续下降趋势，EAPC为-3.47%（-3.58至-3.37）。ASMR 显示持续下降，与 1990 年相比，2019 年下降了近一半（每 10 万人中 3.0 比 7.39），年下降 2.55% [EAPC = -3.36（95% CI：-3.47 至 -3.25）]。与社会人口指数 (SDI) 相关的不平等显着减少，从 1990 年最贫穷国家和最富裕国家之间每 100,000 人超过 190.43 伤残调整生命年 (DALY)（95% CI：-190.83 至 -190.02）减少到 62.85 DALY 2019 年每 10 万人（95% CI -62.81 至 -62.35）。 结论 1990 年至 2019 年，全球消化性溃疡病发病率和死亡率显着下降。这些健康收益与各国 SDI 相关不平等程度的大幅降低是一致的。国家，这与该地区观察到的整体社会经济和健康状况的改善相结合。