Herpes simplex virus (HSV) is the leading cause of genital ulcers worldwide. In rare cases, mostly among immunocompromised hosts, HSV infections can present as hypertrophic pseudotumoral forms simulating malignancies or often mistaken as other viral infections, usually resistant to conventional antiviral therapy and often requiring alternative therapeutic approaches. A high level of clinical suspicion is needed. We present a case of woman living with HIV with pseudotumoral vulvar herpes refractory to oral acyclovir, successfully treated with systemic foscarnet and topical imiquimod.

中文翻译：

---

艾滋病毒感染女性的假性肿瘤性生殖器疱疹：诊断和治疗挑战。

单纯疱疹病毒（HSV）是全世界生殖器溃疡的主要原因。在极少数情况下，主要是在免疫功能低下的宿主中，单纯疱疹病毒感染可以表现为模拟恶性肿瘤的肥厚性假瘤形式，或经常被误认为是其他病毒感染，通常对传统的抗病毒治疗有抵抗力，并且经常需要替代治疗方法。需要高度的临床怀疑。我们介绍了一例患有艾滋病毒的妇女，患有口服阿昔洛韦难治的假瘤性外阴疱疹，经全身膦甲酸和局部咪喹莫特成功治疗。