A commercial bacterial cellulose-monolaurin wound dressing was investigated for changes in the chemical structure, mechanical strength, thermal degradation, morphology, and functional swelling properties after exposure to gamma and electron beam radiations at doses 15-50 kGy. Radiation-induced oxidation occurred as seen in the FT-IR peaks at 1720-1750 cm-1. Degradation of the cellulosic network was observed in tensile strength reduction and shift in degradation temperature to lower values. The SEM cross-section images of the irradiated dressings revealed a less dense nanostructure network compared to the non-irradiated samples while the XRD diffractograms indicated a change in lattice direction/plane. Despite these changes, irradiation caused no significant effect on the functional properties especially at 15-25 kGy doses where most biomedical devices are sterilized. All irradiated wound dressings exhibited physical integrity, increased exudate absorption, and water vapor transmission rate - properties beneficial to wound-healing functionality. The pre-selected sterilization dose of 15 kGy for each ionizing radiation was successfully verified and substantiated following ISO 11137-2:2016, hence ionizing radiation is a suitable sterilization modality for the product.

中文翻译：

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细菌纤维素-月桂酸甘油酯伤口敷料的辐射处理：理化效应、功能分析和灭菌。

研究了商业细菌纤维素-单月桂酸甘油酯伤口敷料在暴露于剂量 15-50 kGy 的伽马和电子束辐射后化学结构、机械强度、热降解、形态和功能膨胀特性的变化。从 1720-1750 cm-1 的 FT-IR 峰中可以看出，发生了辐射诱导的氧化。观察到纤维素网络的降解导致拉伸强度降低并且降解温度转变为较低值。与未辐照样品相比，辐照敷料的 SEM 横截面图像显示纳米结构网络的密度较低，而 XRD 衍射图表明晶格方向/平面发生变化。尽管有这些变化，辐射对功能特性没有造成显着影响，尤其是在大多数生物医学设备灭菌的 15-25 kGy 剂量下。所有经过辐照的伤口敷料都表现出物理完整性、渗出物吸收增加和水蒸气透过率——这些特性有利于伤口愈合功能。每个电离辐射预选的 15 kGy 灭菌剂量已根据 ISO 11137-2:2016 成功验证和证实，因此电离辐射是该产品的合适灭菌方式。