Objectives Oral health problem is prevalent in the elderly population which is also at high risk of Parkinson's disease (PD). However, the association between self-reported oral health and PD is still unclear. We aimed to explore the association between baseline self-reported oral health (mouth ulcers, painful gums, bleeding gums, loosen teeth, toothache, dentures) and future incidence of PD. Methods Participants were enrolled in the UK biobank from 2006 to 2010 and those without PD at baseline were included in the current study. We used Cox regression analysis to explore the question and adjusted for age, sex, body mass index, smoking, drinking, ethnicity, education, socioeconomic status, and average total household income before tax. Results We included 421180 participants with a mean age of 56.26 years old and 46.5% of them were male. And 2339 participants were diagnosed with PD in the follow-up. Mouth ulcers, loosen teeth, dentures, toothache, and bleeding gums were not related to the risk of PD. Painful gums were related to a higher risk of PD (HR: 1.39, 95%CI: 1.12-1.72, P = 0.003), and similar results were reached after adjusting for gene risk (HR: 1.39, 95%CI: 1.12-1.73, P = 0.003), or source of diagnosis (HR: 1.39, 95%CI: 1.12-1.72, P = 0.002), and time of diagnosis (HR: 1.29, 95%CI: 1.03-1.63, P = 0.02). Conclusions Our study has demonstrated a substantial correlation between painful gums and elevated susceptibility to PD, underscoring the potential advantages of implementing oral health interventions for decreasing the risk of PD.

中文翻译：

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自我报告的口腔健康与帕金森病之间的关联：来自英国生物银行的证据。

目标 口腔健康问题在老年人群中普遍存在，也是帕金森病（PD）的高危人群。然而，自我报告的口腔健康与帕金森病之间的关联仍不清楚。我们的目的是探讨基线自我报告的口腔健康状况（口腔溃疡、牙龈疼痛、牙龈出血、牙齿松动、牙痛、假牙）与未来帕金森病发病率之间的关系。方法 参与者于 2006 年至 2010 年在英国生物样本库入组，基线时未患 PD 的参与者也纳入本研究。我们使用 Cox 回归分析来探讨这个问题，并根据年龄、性别、体重指数、吸烟、饮酒、种族、教育程度、社会经济地位和税前平均家庭总收入进行调整。结果 我们纳入了 421180 名参与者，平均年龄为 56.26 岁，其中 46.5% 为男性。随访中有 2339 名参与者被诊断为 PD。口腔溃疡、牙齿松动、假牙、牙痛和牙龈出血与 PD 风险无关。牙龈疼痛与较高的 PD 风险相关（HR：1.39，95%CI：1.12-1.72，P = 0.003），调整基因风险后得出相似的结果（HR：1.39，95%CI：1.12-1.73） ，P = 0.003），或诊断来源（HR：1.39，95％CI：1.12-1.72，P = 0.002），以及诊断时间（HR：1.29，95％CI：1.03-1.63，P = 0.02）。结论 我们的研究证明牙龈疼痛与帕金森病易感性升高之间存在显着相关性，强调了实施口腔健康干预措施对于降低帕金森病风险的潜在优势。