To first induce chronic deep venous thrombosis in the left iliac veins of canines and porcines and then compare these two models to validate endovascular treatment devices. Thrombin and fibrinogen were used to produce a solid thrombus in the left iliac veins of a stenosis model. The researchers used venous angiography and histological staining to investigate the progression of thrombosis. A left iliac vein thrombus was successfully formed in all experimental animals, including six Labrador dogs and three Bama miniature pigs, and there was minimal surgical bleeding. All dogs survived until 90 days, and three pigs died on Days 29, 33, and 58. The researchers first established the models and then observed the progression of chronic deep venous thrombosis of the iliac vein in large animals for up to 90 days. Dogs are better suited for chronic deep venous thrombosis models due to their uncomplicated anatomy, excellent obedience, and proneness to physical activity compared with pigs.

中文翻译：

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犬与猪慢性深静脉血栓模型的比较

首先在犬和猪的左髂静脉中诱导慢性深静脉血栓形成，然后比较这两种模型以验证血管内治疗装置。使用凝血酶和纤维蛋白原在狭窄模型的左髂静脉中产生固体血栓。研究人员使用静脉血管造影和组织学染色来研究血栓形成的进展。所有实验动物（包括6只拉布拉多犬和3只巴马小型猪）均成功形成左髂静脉血栓，且手术出血极少。所有的狗都存活到了90天，三头猪在第29天、第33天和第58天死亡。研究人员首先建立了模型，然后观察了大型动物髂静脉慢性深静脉血栓形成的进展长达90天。与猪相比，狗更适合慢性深静脉血栓形成模型，因为它们的解剖结构简单，服从性好，并且易于进行体力活动。