Phosphodiesterase type 5 plays a crucial role in regulating key signaling molecules involved in various physiological processes. This study combines virtual screening and molecular dynamics simulations to investigate the repurposing of FDA-approved drugs as potential PDE5 inhibitors.

中文翻译：

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通过药物再利用方法识别磷酸二酯酶 5 抑制剂：对血管功能障碍的影响

5 型磷酸二酯酶在调节参与各种生理过程的关键信号分子中发挥着至关重要的作用。这项研究结合了虚拟筛选和分子动力学模拟，以研究 FDA 批准的药物作为潜在 PDE5 抑制剂的重新利用。