While colloquially recognized for its role in pleasure, reward, and affect, dopamine is also necessary for proficient action control. Many motor studies focus on dopaminergic transmission along the nigrostriatal pathway, using Parkinson's disease as a model of a dorsal striatal lesion. Less attention to the mesolimbic pathway and its role in motor control has led to an important question related to the limbic–motor network. Indeed, secondary targets of the mesolimbic pathway include the hippocampus and amygdala, and these are linked to the motor cortex through the substantia nigra and thalamus. The modulatory impact of dopamine in the hippocampus and amygdala in humans is a focus of current investigations. This review explores dopaminergic activity in the mesial temporal lobe by summarizing dopaminergic networks and transmission in these regions and examining their role in behaviour and disease.

中文翻译：

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颞内侧多巴胺：从生物学到行为

虽然多巴胺因其在快乐、奖励和情感中的作用而被通俗地认可，但它对于熟练的行动控制也是必需的。许多运动研究侧重于沿着黑质纹状体通路的多巴胺能传递，使用帕金森病作为背侧纹状体病变的模型。对中脑边缘通路及其在运动控制中的作用的关注较少，导致了与边缘运动网络相关的一个重要问题。事实上，中脑边缘通路的次要目标包括海马体和杏仁核，它们通过黑质和丘脑与运动皮层相连。多巴胺对人类海马体和杏仁核的调节作用是当前研究的焦点。本综述通过总结这些区域的多巴胺能网络和传播并检查它们在行为和疾病中的作用，探讨了内侧颞叶的多巴胺能活动。