Introduction. Anticoagulation treatment is routinely underused in patients with atrial fibrillation (AF), particularly in settings with limited resources. The current study is aimed at evaluating the appropriateness of oral anticoagulation treatment among AF patients at the Yekatit 12 Hospital Medical College (Y12HMC), Addis Ababa, Ethiopia. Methods. Institutional-based retrospective cross-sectional study conducted in Y12HMC from November 2019 to March 2020. During the study period, 256 patients’ medical records were found; 231 of them met the eligibility criteria and were included in the study. The data were analyzed using SPSS version 25, descriptive statistics were used to summarize the data, and binary logistic regression was performed to identify predictors of inappropriate anticoagulation management. Results. The majority of study participants were males (55.8%), and over half of them (57.6%) had a nonvalvular type of AF. The majority of patients (61.9%) were receiving anticoagulant treatment, and of them, warfarin was prescribed to most of the study subjects (71.3%). Nearly half (47.6%) of the study participants had inappropriate anticoagulation treatment; among these, the majority of them (69.1%) were from a valvular type of AF. Patients with a valvular type of AF and having the diagnosis of congestive heart disease as comorbidity showed a statistically significant association towards inappropriate anticoagulation management. Conclusion. According to the study, a significant portion of AF patients received inappropriate anticoagulant treatment, which may play a significant role for the increased risk of stroke in these groups of patients. All of the inappropriate cases were due to failure to start anticoagulant treatment.

中文翻译：

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资源有限环境下房颤患者口服抗凝药不当使用的患病率和决定因素

介绍。房颤 (AF) 患者的抗凝治疗通常未得到充分利用，特别是在资源有限的环境中。目前的研究旨在评估埃塞俄比亚亚的斯亚贝巴 Yekatit 12 医院医学院 (Y12HMC) 房颤患者口服抗凝治疗的适当性。方法。2019年11月至2020年3月在Y12HMC进行的基于机构的回顾性横断面研究。研究期间，发现256名患者的病历；其中 231 人符合资格标准并被纳入研究。使用 SPSS 25 版分析数据，使用描述性统计总结数据，并进行二元逻辑回归以确定不适当抗凝管理的预测因子。结果。大多数研究参与者是男性（55.8%），其中超过一半（57.6%）患有非瓣膜性房颤。大多数患者（61.9%）正在接受抗凝治疗，其中大多数研究对象（71.3%）都服用了华法林。近一半（47.6%）的研究参与者接受了不适当的抗凝治疗；其中，大多数（69.1%）来自瓣膜型房颤。瓣膜型房颤且被诊断为合并症的充血性心脏病患者与不适当的抗凝治疗存在统计学显着相关性。结论。研究表明，很大一部分房颤患者接受了不适当的抗凝治疗，这可能是导致这些患者中风风险增加的重要原因。所有不适当的病例都是由于未能开始抗凝治疗所致。