Whole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. We therefore performed the present systematic review of the available scientific literature on the issue. The review was conducted following the guidelines by the Space Biomedicine Systematic Review Group, based on Cochrane review guidelines. The relevant context or environment of the studies was “ground-based environment”; space analogs or diseased conditions were not included. The search retrieved 801 studies; 77 articles were selected for further consideration after an initial screening. Thirty-three studies met the inclusion criteria. The main variables related to blood markers involved angiogenic and endothelial factors, fibrinolysis and coagulation markers, cytokine levels, inflammatory and plasma oxidative stress markers. Functional and hemodynamic markers involved blood pressure measurements, systemic vascular resistance, blood flow and microvascular and endothelial functions. The available evidence suggests neutral or potentially positive effects of short- and long-term interventions with WBV and RVE on variables related to blood coagulation, fibrinolysis, inflammatory status, oxidative stress, cardiovascular, microvascular and endothelial functions. No significant warning signs towards an increased risk of undesired clotting and venous thrombosis were identified. If confirmed by further studies, WBV and RVE could be part of the countermeasures aimed at preventing or attenuating the muscular and cardiovascular deconditioning associated with spaceflights, permanence on planetary habitats and ground-based simulations of microgravity.

全身振动（WBV）和阻力振动运动（RVE）被用来作为对抗骨质流失、肌肉萎缩和身体状况不佳的对策。就诱发不良血液凝固和静脉血栓形成的风险而言，干预措施的安全性尚不清楚。因此，我们对有关该问题的现有科学文献进行了系统回顾。该审查是根据空间生物医学系统审查小组的指导方针进行的，该指导方针基于 Cochrane 审查指南。研究的相关背景或环境是“地基环境”；空间类似物或疾病状况不包括在内。检索检索到 801 项研究；经过初步筛选，最终选出 77 篇文章供进一步考虑。三十三项研究符合纳入标准。与血液标志物相关的主要变量包括血管生成和内皮因子、纤溶和凝血标志物、细胞因子水平、炎症和血浆氧化应激标志物。功能和血流动力学标志物涉及血压测量、全身血管阻力、血流量以及微血管和内皮功能。现有证据表明，WBV 和 RVE 的短期和长期干预对与凝血、纤溶、炎症状态、氧化应激、心血管、微血管和内皮功能相关的变量具有中性或潜在的积极影响。没有发现任何显着的警告信号表明不良凝血和静脉血栓形成的风险增加。如果进一步研究得到证实，WBV 和 RVE 可能成为预防或减轻与太空飞行、行星栖息地持久性和地面微重力模拟相关的肌肉和心血管功能失调的对策的一部分。