Background Multiple studies have shown the SARS-CoV-2 virus (COVID-19) to be associated with deleterious outcomes in a wide range of patients. The impact of COVID-19 has not been well investigated among burned patients. We suspect that patients will have worsened respiratory and thrombotic complications, ultimately leading to increased mortality. The objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn injury. Methods This is a retrospective, propensity matched, cohort study. We examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 January 2020, to 31 July 2021, and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease, tenth revision (ICD-10) codes. Study participants included adults who were treated for a burn injury during the study period. Results We included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection (total 1472 patients, mean age 36.3 ± 24.3). We found no significant increase in mortality observed for patients with concurrent COVID-19 (OR 1.203, 95% CI 0.517–2.803; p = 0.6675). We did observe significant increase in infections (OR 3.537, 95% CI 2.798–4.471; p = 0.0001), thrombotic complications (OR 2.342, 95% CI 1.351–4.058; p = 0.0018), as was the incidence of hypertrophic scarring (OR 3.368, 95% CI 2.326–4.877; p = 0.0001). Conclusions We observed that concurrent COVID-19 infection was associated with an increase in infections, thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

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COVID-19对烧伤患者临床结果的影响

背景 多项研究表明 SARS-CoV-2 病毒 (COVID-19) 与多种患者的有害结果相关。COVID-19 对烧伤患者的影响尚未得到充分研究。我们怀疑患者的呼吸系统和血栓并发症会恶化，最终导致死亡率增加。本研究的目的是确定同时感染 COVID-19 对烧伤后临床结果的影响。方法 这是一项回顾性、倾向匹配的队列研究。我们检查了美国 75 个医疗保健协会超过 7500 万名患者的电子病历去识别化数据库，其中包括 2020 年 1 月 1 日至 2021 年 7 月 31 日期间接受热烧伤治疗的患者以及那些被诊断出患有新冠肺炎的患者。根据国际疾病分类第十修订版 (ICD-10) 代码，受伤前或受伤后一天内发生 19 例感染。研究参与者包括在研究期间接受烧伤治疗的成年人。结果 我们纳入了 736 名烧伤且并发 COVID-19 感染的患者，与 736 名烧伤且不并发 COVID-19 感染的患者相匹配（总共 1472 名患者，平均年龄 36.3 ± 24.3 岁）。我们发现并发 COVID-19 的患者死亡率没有显着增加（OR 1.203，95% CI 0.517–2.803；p = 0.6675）。我们确实观察到感染（OR 3.537，95% CI 2.798–4.471；p = 0.0001）、血栓并发症（OR 2.342，95% CI 1.351–4.058；p = 0.0018）以及肥厚性疤痕的发生率显着增加（OR 2.342，95% CI 1.351–4.058；p = 0.0018）。 3.368，95% CI 2.326–4.877；p = 0.0001）。结论 我们观察到，在我们的烧伤患者队列中，并发 COVID-19 感染与感染、血栓形成和肥厚性疤痕增加有关，但死亡率没有增加。