Transmembrane proteins are active in amphipathic environments. To stabilize the protein in such surrounding the exposure of hydrophobic residues on the protein surface is required. Transmembrane proteins are responsible for the transport of various molecules. Therefore, they often represent structures in the form of channels. This analysis focused on the stability and local flexibility of transmembrane proteins, particularly those related to their biological activity. Different forms of anchorage were identified using the fuzzy oil-drop model (FOD) and its modified form, FOD-M. The mainly helical as well as β-barrel structural forms are compared with respect to the mechanism of stabilization in the cell membrane. The different anchoring system was found to stabilize protein molecules with possible local fluctuation.

中文翻译：

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跨膜蛋白——不同的锚定系统

跨膜蛋白在两亲环境中具有活性。为了在这样的环境中稳定蛋白质，需要在蛋白质表面上暴露疏水性残基。跨膜蛋白负责各种分子的运输。因此，它们通常以通道的形式表示结构。该分析重点关注跨膜蛋白的稳定性和局部灵活性，特别是那些与其生物活性相关的蛋白。使用模糊油滴模型 (FOD) 及其修改形式 FOD-M 来识别不同形式的锚固。主要的螺旋结构和β-桶结构形式在细胞膜稳定机制方面进行了比较。发现不同的锚定系统可以稳定可能存在局部波动的蛋白质分子。