Florfenicol (FFC) is a broad-spectrum antibiotic approved by the U.S. Food and Drug Administration to treat both systemic and external bacterial infections in food fish. The objective of this study was to evaluate the effect of FFC-medicated feed on the gut microbiota of Zebrafish Danio danio to determine (1) if the therapeutic dose of FFC-medicated feed induces dysbiosis and (2) if fish with altered gut microbiota were more susceptible to subsequent infection by the common opportunistic fish pathogen Aeromonas hydrophila.

中文翻译：

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在建议停药期后，氟苯尼考引起的肠道菌群失调会增加斑马鱼斑马鱼嗜水气单胞菌感染的易感性

氟苯尼考 (FFC) 是一种经美国食品和药物管理局批准的广谱抗生素，用于治疗食用鱼的全身和外部细菌感染。本研究的目的是评估含 FFC 的饲料对斑马鱼Danio danio肠道微生物群的影响，以确定 (1) 治疗剂量的含 FFC 的饲料是否会引起菌群失调，以及 (2) 肠道微生物群改变的鱼是否会出现肠道菌群失调。更容易受到常见机会性鱼类病原体嗜水气单胞菌的后续感染。