Bscl2 plays a role in lipid metabolism of mammals, however its role in teleost fish remains unclear. Using the grass carp (Ctenopharyngodon idella) as a model, the bscl2 gene was isolated from the brain and characterized. Thereafter, the tissue distribution of the gene was examined, before expression was analyzed as a function of fasting, refeeding, oral glucose administration and overfeeding. In addition, bscl2 mRNA levels were evaluated in grass carp primary hepatocytes treated with glucagon, insulin, oleic acid, and glucose. Results showed that the cloned bscl2 gene was 1341 bp, encoding 446 amino acids, and was highly expressed in the brain, heart, and gonad. Following oral glucose administration, bscl2 expression increased. Expression of bscl2 decreased in fasted fish but increased following refeeding. Overfeeding, which resulted in elevated lipid accumulation, also stimulated bscl2 expression. In primary hepatocytes, bscl2 levels were increased by glucose, oleic acid, and insulin treatments, and reduced by glucagon treatment. These data suggest that bscl2 may play an important role in nutrient metabolism in teleost fish.

Bscl2在哺乳动物的脂质代谢中发挥作用，但其在硬骨鱼中的作用尚不清楚。以草鱼（Ctenopharyngodon idella）为模型，bscl2从大脑中分离出基因并进行表征。此后，检查该基因的组织分布，然后分析表达作为禁食、重新进食、口服葡萄糖施用和过量进食的函数。此外，在用胰高血糖素、胰岛素、油酸和处理的草鱼原代肝细胞中评估了bscl2 mRNA水平。葡萄糖。结果显示，克隆的bscl2基因全长1341 bp，编码446个氨基酸，在大脑、心脏和性腺中高表达。口服葡萄糖后，bscl2表达增加。 bscl2 的表达在禁食的鱼中下降，但在重新喂食后增加。过度喂养会导致脂质积累增加，也会刺激bscl2表达。在原代肝细胞中，bscl2 水平因葡萄糖、油酸和胰岛素治疗而升高，因胰高血糖素治疗而降低。这些数据表明bscl2可能在硬骨鱼的营养代谢中发挥重要作用。