当前位置: X-MOL 学术Clin. Endocrinol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Low-dose diazoxide is safe and effective in infants with transient hyperinsulinism
Clinical Endocrinology ( IF 3.2 ) Pub Date : 2023-12-07 , DOI: 10.1111/cen.14987
Neha Malhotra 1 , Daphne Yau 2 , Annaruby Cunjamalay 1 , Buddhi Gunasekara 1 , Athanasakopoulou S. 3 , Clare Gilbert 1 , Kate Morgan 1 , Mehul Dattani 1 , Antonia Dastamani 1
Affiliation  

Transient hyperinsulinism (THI) is the most common form of recurrent hypoglycaemia in neonates beyond the first week of life. Although self-resolving, treatment can be required. Consensus guidelines recommend the lower end of the diazoxide 5–15 mg/kg/day range in THI to reduce the risk of adverse events. We sought to determine if doses <5 mg/kg/day of diazoxide can be effective in THI.

中文翻译:

低剂量二氮嗪对于患有短暂性高胰岛素血症的婴儿是安全有效的

短暂性高胰岛素血症 (THI) 是出生后第一周后新生儿复发性低血糖的最常见形式。虽然可以自行解决,但可能需要治疗。共识指南建议 THI 中二氮嗪的下限为 5–15 mg/kg/天,以降低不良事件的风险。我们试图确定剂量<5 mg/kg/天的二氮嗪是否可以有效治疗 THI。
更新日期:2023-12-07
down
wechat
bug