Genome-wide association studies pinpoint genetic risk factors for neurodevelopmental disorders (NDDs), but the next challenge is to understand the mechanisms through which these genes affect brain development. Two recent CRISPR screens in human brain organoids^1,2 interrogate the function of risk genes for autism spectrum disorder and other NDDs.

中文翻译：

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通过 CRISPR 理解人类大脑发育中的基因功能

全基因组关联研究查明神经发育障碍（NDD）的遗传风险因素，但下一个挑战是了解这些基因影响大脑发育的机制。最近在人脑类器官中进行的两项 CRISPR 筛选^{1 , 2}探讨了自闭症谱系障碍和其他 NDD 的风险基因的功能。