Abstract

Following the transcription step, the newly synthesized mRNA is exported from the nucleus to the cytoplasm and further to the translation site. The TREX-2 complex is involved in the step of mRNA export from the nucleus to the cytoplasm. This complex in Drosophila melanogaster consists of four proteins: Xmas-2, PCID2, ENY2, and Sem1p. In our work, we have shown that deletion of the C-terminal sequence of PCID2 leads to a decrease in the interaction of the protein with RNA and to impaired mRNA export from the nucleus to the cytoplasm in D. melanogaster.

中文翻译：

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果蝇中 mRNA 与 PCID2（TREX-2 复合体的一个亚基）C 端结构域的相互作用是其从细胞核输出到细胞质所必需的

摘要

转录步骤之后，新合成的 mRNA 从细胞核输出到细胞质，并进一步输出到翻译位点。TREX-2复合物参与mRNA从细胞核输出到细胞质的步骤。果蝇中的这种复合物由四种蛋白质组成：Xmas-2、PCID2、ENY2 和 Sem1p。在我们的工作中，我们发现，在黑腹果蝇中，PCID2 C 端序列的缺失会导致蛋白质与 RNA 的相互作用减少，并导致 mRNA 从细胞核到细胞质的输出受损。