Novel dual-targeting inhibitors of NSD2 and HDAC2 for the treatment of liver cancer: structure-based virtual screening, molecular dynamics simulation, and in vitro and in vivo biological activity evaluations,Journal of Enzyme inhibition and Medicinal Chemistry

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Novel dual-targeting inhibitors of NSD2 and HDAC2 for the treatment of liver cancer: structure-based virtual screening, molecular dynamics simulation, and in vitro and in vivo biological activity evaluations
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-12-07 , DOI: 10.1080/14756366.2023.2289355
Xing Jin ₁ , Yuting Wang ₂ , Jing Chen ₁ , Miaomiao Niu ₂ , Yang Yang ₁ , Qiaoxuan Zhang _{3,

4} , Guangyu Bao ₁

Affiliation

Liver cancer exhibits a high degree of heterogeneity and involves intricate mechanisms. Recent research has revealed the significant role of histone lysine methylation and acetylation in the epigen...

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