Atherosclerosis is induced by the persistent inflammation of the arterial wall. The regulation of inflammation through active drugs can mitigate atherosclerotic lesions, but the therapeutic outcome is limited due to its insufficient efficacy and stability. Herein, a PdH-Te nanozyme with excellent reactive oxygen species (ROS) scavenging capability is designed for anti-inflammatory therapy, thereby preventing foam cell formation to alleviate atherosclerosis. As expected, the PdH-Te nanozyme shows outstanding multiple antioxidant enzyme activities and sustained hydrogen release properties. Benefiting from decreased ROS levels by enzyme catalysis, PdH-Te nanozyme significantly suppresses the pro-inflammatory cytokines for atherosclerosis treatment. Taken together, the presented results demonstrate that inhibition of inflammation based on PdH-Te nanozyme can effectively treat atherosclerosis, identifying an attractive strategy against cardiovascular diseases.

中文翻译：

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PdH-Te 纳米酶持续释放氢气用于动脉粥样硬化抗炎治疗

动脉粥样硬化是由动脉壁的持续炎症引起的。通过活性药物调节炎症可以减轻动脉粥样硬化病变，但由于其疗效和稳定性不足，治疗效果有限。在此，设计了一种具有优异活性氧（ROS）清除能力的PdH-Te纳米酶用于抗炎治疗，从而防止泡沫细胞形成，从而缓解动脉粥样硬化。正如预期的那样，PdH-Te纳米酶表现出出色的多种抗氧化酶活性和持续的氢释放特性。受益于酶催化降低 ROS 水平，PdH-Te 纳米酶显着抑制促炎细胞因子，用于动脉粥样硬化治疗。总而言之，所呈现的结果表明，基于 PdH-Te 纳米酶的炎症抑制可以有效治疗动脉粥样硬化，从而确定了一种针对心血管疾病的有吸引力的策略。