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Surfactant as a drug carrier
Seminars in Fetal and Neonatal Medicine ( IF 3 ) Pub Date : 2023-11-23 , DOI: 10.1016/j.siny.2023.101499
Arun Sett , Charles C. Roehr , Brett J. Manley

Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by delivering therapeutic agents directly to the respiratory system. The inherent chemical properties of surfactant allows it to readily distribute throughout the respiratory system. Therapeutic agents delivered by surfactant can primarily confer additional benefits but have potential to improve surfactant function. It is critically important that additional agents do not interefere with the innate surface tension lowering function of surfactant. Systemic evaluation through benchtop, translational and human trials are required to translate this potential technique into clinical practice.



中文翻译:

表面活性剂作为药物载体

使用表面活性剂载体的药物输送有可能通过将治疗剂直接输送到呼吸系统来预防全身副作用。表面活性剂的固有化学特性使其能够轻松分布在整个呼吸系统中。由表面活性剂提供的治疗剂主要可以带来额外的益处,但有可能改善表面活性剂的功能。至关重要的是,其他试剂不得干扰表面活性剂固有的降低表面张力的功能。需要通过台式、转化和人体试验进行系统评估,才能将这种潜在技术转化为临床实践。

更新日期:2023-11-23
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