During task-based functional magnetic resonance imaging (t-fMRI) patients with depressive disorder (DD) have shown abnormal caudate nucleus activation. There have been no meta-analyses that are conducted on the caudate nucleus using Activation Likelihood Estimation (ALE) in patients with DD, and the relationships between abnormal caudate activity and different behavior domains in patients with DD remain unclear. There were 24 previously published t-fMRI studies included in the study with the caudate nucleus as the region of interest. Meta-analyses were performed using the method of ALE. Included five ALE meta-analyses: (1) the hypoactivated caudate nucleus relative to healthy controls (HCs); (2) the hyper-activated caudate nucleus; (3) the abnormal activation in the caudate nucleus in the emotion domain; (4) the abnormal activation in cognition domain; (5) the abnormal activation in the affective cognition domain. Results revealed that the hypo-/hyper-activity in the caudate subregions is mainly located in the caudate body and head, while the relationships between abnormal caudate subregions and different behavior domains are complex. The hypoactivation of the caudate body and head plays a key role in the emotions which indicates there is a positive relationship between the decreased caudate activity and depressed emotional behaviors in patients with DD.

在基于任务的功能磁共振成像 (t-fMRI) 中，抑郁症 (DD) 患者表现出异常的尾状核激活。目前还没有使用激活似然估计 (ALE) 对 DD 患者尾状核进行荟萃分析，并且 DD 患者尾状核异常活动与不同行为领域之间的关系仍不清楚。该研究中纳入了 24 项先前发表的 t-fMRI 研究，以尾状核为感兴趣区域。采用 ALE 方法进行荟萃分析。包括五项 ALE 荟萃分析：(1) 相对于健康对照 (HC) 的尾状核低活性；(2) 尾状核过度活跃；(3)情绪域尾状核异常激活；(4)认知域激活异常；(5)情感认知域异常激活。结果显示，尾状亚区的低/高活动主要位于尾状体和头部，而异常的尾状亚区与不同行为域之间的关系是复杂的。尾核体和头部的低活性在情绪中起着关键作用，这表明 DD 患者尾核活动减少与抑郁情绪行为之间存在正相关关系。