Bipolar disorder (BD) and schizophrenia (SCZ) may exhibit functional abnormalities in several brain areas, including the medial temporal and prefrontal cortex and hippocampus; however, a less explored topic is how brain connectivity is linked to premorbid trauma experiences and clinical features in non-Caucasian samples of SCZ and BD. Methods: Sixty-two individuals with SCZ ( = 20), BD ( = 21), and healthy controls (HC, = 21) from indigenous and African ethnicity were submitted to clinical screening (Di-PAD), traumata experiences (ETISR-SF), cognitive and functional MRI assessment. The item psychosis/hallucinations in SCZ patients showed a negative correlation with the global efficiency (GE) in the right dorsal attention network. The items mania, irritable mood, and racing thoughts in the Di-PAD scale had a significant negative correlation with the GE in the parietal right default mode network. Conclusions: Differences in the activation of specific networks were associated with earlier disease onset, history of physical abuse, and more severe psychotic and mood symptoms in SCZ and BD subjects of indigenous and black ethnicity. Findings provide further evidence on SZ and BD's brain connectivity disturbances, and their clinical significance, in non-Caucasian samples.

中文翻译：

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静息态功能磁共振成像与患有双相情感障碍和精神分裂症的非洲人后裔的创伤经历、情绪和精神病有关

双相情感障碍 (BD) 和精神分裂症 (SCZ) 可能会在多个大脑区域表现出功能异常，包括内侧颞叶、前额皮质和海马体；然而，一个较少探讨的话题是，在非白种人 SCZ 和 BD 样本中，大脑连接性如何与病前创伤经历和临床特征相关。方法：来自土著和非洲种族的 62 名 SCZ (= 20)、BD (= 21) 和健康对照 (HC, = 21) 个体接受了临床筛查 (Di-PAD)、创伤经历 (ETISR-SF) ）、认知和功能 MRI 评估。 SCZ 患者的精神病/幻觉项目与右背侧注意力网络的全局效率（GE）呈负相关。 Di-PAD量表中的项目躁狂、烦躁情绪和急躁思绪与顶叶右默认模式网络中的GE呈显着负相关。结论：土著和黑人的 SCZ 和 BD 受试者中特定网络激活的差异与较早的疾病发作、身体虐待史以及更严重的精神病和情绪症状有关。研究结果为非白种人样本中 SZ 和 BD 的大脑连接障碍及其临床意义提供了进一步的证据。