Background

Centrally collected Finnish national health register data on adverse pregnancy outcomes are available for research, but the validity of the data is largely unknown. Our aim was to compare the diagnoses of preeclampsia (PE), gestational diabetes (GDM), and preterm delivery from hospital records with the registry based diagnoses from the Finnish Care Register for Health Care (FCR). Data on gestational age at delivery from the Medical Birth Registry (MBR) was also studied.

Methods

The Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) Study cohort was used as a data source. Each diagnosis was ascertained from electronic hospital records. The validity of diagnoses obtained by record linkage of FCR and MBR was assessed against the classification previously confirmed independently by a research nurse and a study physician.

Results

Sensitivity of PE diagnoses in FCR was 80.3 % (95 % CI 78.3 % to 82.2 %) and specificity 95.3 % (95 % CI 93.9 % to 96.4 %). Sensitivity for GDM was 64.1 % (95 % CI: 58.7 % − 69.3 %) and specificity 98.5 % (95 % CI: 97.9 % − 98.9 %), whereas sensitivity and specificity for preterm delivery were 32.4 % (95 % CI: 29.0 % − 36.0 %) and 99.7 % (95 % CI: 99.3 % − 99.9 %). Sensitivity of preterm delivery in the MBR was 99.1 % and specificity 99.9 %.

Conclusions

FCR registry diagnoses for PE have satisfactory sensitivity and high specificity. Diagnoses for GDM and preterm delivery have lower sensitivity limiting their use in studies, and data from MBR should be preferred when studying preterm deliveries.

中文翻译：

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验证芬兰医疗保健登记册中针对先兆子痫、妊娠糖尿病和早产的医疗保健诊断

背景

集中收集的芬兰国家健康登记数据可用于研究，但数据的有效性很大程度上未知。我们的目的是将医院记录中的先兆子痫 (PE)、妊娠糖尿病 (GDM) 和早产的诊断与芬兰医疗保健登记处 (FCR) 的登记诊断进行比较。还研究了医学出生登记处 (MBR) 的分娩胎龄数据。

方法

芬兰先兆子痫遗传学联盟 (FINNPEC) 研究队列被用作数据源。每个诊断都是根据医院的电子记录确定的。通过 FCR 和 MBR 记录关联获得的诊断的有效性根据研究护士和研究医生之前独立确认的分类进行评估。

结果

FCR 中 PE 诊断的敏感性为 80.3%（95% CI 78.3% 至 82.2%）， 特异性为 95.3%（95% CI 93.9% 至 96.4%）。GDM 的敏感性为 64.1 % (95 % CI: 58.7 % − 69.3 %)，特异性为 98.5 % (95 % CI: 97.9 % − 98.9 %)，而早产的敏感性和特异性为 32.4 % (95 % CI: 29.0 %) − 36.0 %) 和 99.7 % (95 % CI: 99.3 % − 99.9 %)。MBR 中早产的敏感性为 99.1%，特异性为 99.9%。

结论

FCR登记诊断PE具有令人满意的敏感性和高特异性。GDM 和早产的诊断敏感性较低，限制了它们在研究中的使用，在研究早产时应首选 MBR 数据。