Abstract

Pulmonary surfactant, which is a complex mixture of lipids and proteins, plays a key role in the functional properties of the respiratory system. Lipids form complexes with proteins to maintain low values of surface tension at continuous compression/expansion deformations. However, interactions that lead to the complexation still remain to be unknown thus significantly hampering the development of synthetic analogs of the natural pulmonary surfactant. In this work, the methods of surface rheology and ellipsometry have been employed to study the dynamic properties of model phospholipid monolayers applied onto the surfaces of synthetic polyelectrolyte solutions. It has been shown, that electrostatic or hydrophobic interactions between lipids and macromolecules are insufficient for the efficient complexation and maintenance of low surface tension values.

中文翻译：

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聚苯乙烯磺酸钠和聚二烯丙基二甲基氯化铵溶液表面肺脂质单分子层的动态特性

摘要

肺表面活性物质是脂质和蛋白质的复杂混合物，在呼吸系统的功能特性中起着关键作用。脂质与蛋白质形成复合物，以在连续压缩/膨胀变形时保持较低的表面张力值。然而，导致络合的相互作用仍然未知，因此严重阻碍了天然肺表面活性剂的合成类似物的开发。在这项工作中，采用表面流变学和椭圆光度法的方法来研究应用于合成聚电解质溶液表面的模型磷脂单层的动态特性。已经表明，脂质和大分子之间的静电或疏水相互作用不足以有效络合和维持低表面张力值。