Diffuse large B-cell lymphoma (DLBCL) is one of the malignancies at high risk for the development of venous thromboembolism (VTE). We aimed to evaluate the incidence of VTE and the predictive ability of the age-adjusted international prognostic index (aaIPI) for the prediction of VTE among DLBCL patients. This was a retrospective cohort study including adult patients with newly diagnosed DLBCL. Differences in VTE occurrence within one year after diagnosis of DLBCL were estimated across aaIPI groups using the Kaplan-Meier model, Cox’s model, and Gray’s model with deaths regarded as competing events. Five hundred and ninety-one newly diagnosed DLBCL patients with a median age of 58 (range 16–93) years were included in this study. At a median follow-up time of 365 (range 2-365) days, VTE events were objectively diagnosed in 32 patients, giving a one-year cumulative incidence of VTE of 5.4% (95% confidence interval [CI], 3.7–7.6). Patients with aaIPI ≥ 2 had a significantly higher risk of VTE than patients with aaIPI < 2 (hazard ratio, 3.5; 95% CI, 1.6–7.8; p = 0.001 based on Cox’s model and sub-distribution hazard ratio, 3.0; 95% CI, 1.3–6.7; p = 0.007 using Gray’s model). The C-statistic of aaIPI was 0.65 (95% CI, 0.58–0.72). We demonstrated that the incidence of VTE in Asian DLBCL patients was not uncommon. The aaIPI was effective in determining the risk of VTE in DLBCL patients, even when including death as a competing event. aaIPI may be helpful in identifying patients at higher risk of VTE in DLBCL patients.

弥漫性大 B 细胞淋巴瘤 (DLBCL) 是发生静脉血栓栓塞 (VTE) 的高风险恶性肿瘤之一。我们的目的是评估 DLBCL 患者 VTE 的发生率以及年龄调整国际预后指数 (aaIPI) 对 VTE 预测的预测能力。这是一项回顾性队列研究，包括新诊断的 DLBCL 成年患者。使用 Kaplan-Meier 模型、Cox 模型和 Gray 模型评估了 aaIPI 组在诊断 DLBCL 后一年内 VTE 发生率的差异，其中死亡被视为竞争事件。本研究纳入了 591 名新诊断的 DLBCL 患者，中位年龄为 58 岁（范围 16-93）。中位随访时间为 365 天（范围 2-365），客观诊断了 32 名患者的 VTE 事件，VTE 的一年累积发生率为 5.4%（95% 置信区间 [CI]，3.7-7.6） ）。aaIPI ≥ 2 的患者发生 VTE 的风险显着高于 aaIPI < 2 的患者（风险比，3.5；95% CI，1.6–7.8； 基于 Cox 模型和亚分布风险比，3.0；95%，p = 0.001 ） CI，1.3–6.7；p  = 0.007（使用格雷模型）。aaIPI 的 C 统计量为 0.65（95% CI，0.58-0.72）。我们证明亚洲 DLBCL 患者中 VTE 的发生率并不少见。即使将死亡作为竞争事件，aaIPI 也能有效确定 DLBCL 患者的 VTE 风险。aaIPI 可能有助于识别 DLBCL 患者中 VTE 风险较高的患者。