Urinary and intestinal schistosomiasis are endemic in Senegal, with prevalence heterogeneous throughout the country. Because of their way of life, nomadic pastoralists are not typically included in epidemiological surveys, and data on the prevalence of schistosomiasis in Senegalese nomadic populations are largely non-existent. The purpose of this study was to determine the seroprevalence of schistosomiasis in Senegalese nomadic pastoralists. A modified snowball sampling survey was conducted among 1,467 nomadic pastoralists aged 6 mo and older in 5 districts in northern Senegal. Dried blood spots from participants of all ages and data regarding demographics were collected to assess IgG antibody responses against Schistosoma mansoni soluble egg antigen (SEA) using a bead-based multiplex assay. Out of 1,467 study subjects, 1,464 (99.8%) provided IgG serological data that cleared quality assurance. Of the participants with appropriate data, 56.6% were male, the median age was 22 yr, and 31.6% were under 15 yr of age. The overall anti-SEA IgG seroprevalence was 19.1% (95% confidence interval [CI]: 17.1–21.1%) with the highest estimates observed in Dagana (35.9%) and the lowest observed in Podor nomadic groups (3.4%). Antibody responses increased significantly with age except for the oldest age groups (>40 yr of age), which saw lower levels of antibody response compared to younger adults. When controlling for age and location by multivariate regression, the male sex was associated with a 2-fold greater odds of anti-SEA IgG seropositivity (aPOR: 2.0; 95% CI: 1.5–2.7). Serosurveys for anti-SEA IgG among nomadic peoples in northern Senegal found a substantial percentage of individuals with evidence for current or previous Schistosoma spp. infection with the highest levels of exposure in the district adjacent to the Diama dam along the Senegal River. With IgG prevalence increased by age except in the older adults, and the male sex significantly associated with seropositivity, these data point toward sex-associated behavioral practices and human environmental modification as risk factors for Schistosoma exposure.

泌尿道和肠道血吸虫病是塞内加尔的地方病，全国各地的患病率存在​​差异。由于生活方式的原因，游牧民通常不被纳入流行病学调查，塞内加尔游牧人口中血吸虫病患病率的数据基本上不存在。本研究的目的是确定塞内加尔游牧牧民中血吸虫病的血清流行率。对塞内加尔北部 5 个地区的 1,467 名 6 个月及以上游牧民进行了修改后的滚雪球抽样调查。收集所有年龄段参与者的干血斑和人口统计数据，以使用基于微珠的多重测定来评估针对曼氏血吸虫可溶性卵抗原 (SEA) 的 IgG 抗体反应。在 1,467 名研究对象中，1,464 名 (99.8%) 提供了通过质量保证的 IgG 血清学数据。在拥有适当数据的参与者中，56.6%为男性，中位年龄为22岁，31.6%年龄在15岁以下。总体抗 SEA IgG 血清阳性率为 19.1%（95% 置信区间 [CI]：17.1-21.1%），其中在达加纳观察到的估计值最高（35.9%），在波多尔游牧群体中观察到的估计值最低（3.4%）。抗体反应随着年龄的增长而显着增加，但最大年龄组（> 40 岁）除外，与年轻人相比，该年龄组的抗体反应水平较低。当通过多变量回归控制年龄和地点时，男性与抗 SEA IgG 血清阳性的几率高出 2 倍相关（aPOR：2.0；95% CI：1.5-2.7）。对塞内加尔北部游牧民族进行的抗 SEA IgG 血清调查发现，相当大比例的人具有当前或以前存在血吸虫属的证据。塞内加尔河沿岸迪亚马大坝附近地区的感染暴露程度最高。除老年人外，IgG 患病率随着年龄的增长而增加，并且男性与血清阳性显着相关，这些数据表明与性别相关的行为习惯和人类环境改变是血吸虫暴露的危险因素。