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Ligand-based pharmacophore modelling, structure optimisation, and biological evaluation for the identification of 2-heteroarylthio-N-arylacetamides as novel HSP90 C-terminal inhibitors
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-12-11 , DOI: 10.1080/14756366.2023.2290912 Yajun Liu 1 , Chenyao Li 1 , Yajing Li 1 , Shuming Zhang 1 , Ning Zhang 1 , Xiaobo Bian 2 , Shutao Tan 3
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-12-11 , DOI: 10.1080/14756366.2023.2290912 Yajun Liu 1 , Chenyao Li 1 , Yajing Li 1 , Shuming Zhang 1 , Ning Zhang 1 , Xiaobo Bian 2 , Shutao Tan 3
Affiliation
Targeting Heat shock protein 90 (HSP90) C-terminus is an important strategy to develop HSP90 inhibitors without inducing heat shock response. The development of C-terminal inhibitors, however, is h...
中文翻译：
基于配体的药效团建模、结构优化和生物学评估，用于鉴定 2-杂芳硫基-N-芳基乙酰胺作为新型 HSP90 C 末端抑制剂
靶向热休克蛋白 90 (HSP90) C 末端是开发不诱导热休克反应的 HSP90 抑制剂的重要策略。然而，C 末端抑制剂的开发却...
更新日期：2023-12-14
中文翻译：
基于配体的药效团建模、结构优化和生物学评估，用于鉴定 2-杂芳硫基-N-芳基乙酰胺作为新型 HSP90 C 末端抑制剂
靶向热休克蛋白 90 (HSP90) C 末端是开发不诱导热休克反应的 HSP90 抑制剂的重要策略。然而，C 末端抑制剂的开发却...
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