Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway,Journal of Enzyme inhibition and Medicinal Chemistry

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Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-12-11 , DOI: 10.1080/14756366.2023.2286183
Hao Zhou ₁ , Mengjiao Li ₁ , Hui Liu ₂ , Zheng Liu ₃ , Xuekun Wang ₁ , Shiben Wang ₁

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In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity as...

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