Circular RNA (circRNA) is a class of RNA with the 5' and 3' ends connected covalently to form a closed loop structure and characterized by high stability, conserved sequences and tissue specificity, which is caused by special reverse splicing methods. Currently, it has become a hot spot for research. With the discovery of its powerful regulatory functions and roles, the molecular mechanisms and future value of circRNA in participating in and regulating biological and pathological processes are becoming increasingly apparent. Among them is the increasing prevalence of cardiovascular diseases (CVDs). Many studies have elucidated that circRNA plays a crucial role in the development and progression of CVDs. Therefore, circRNA shows its advantages and brilliant expectations in the field of CVDs. In this review, we describe the biogenesis, bioinformatics detection and function of circRNA and discuss the role of circRNA and its effects on CVDs, including atherosclerosis, myocardial infarction, cardiac hypertrophy and heart failure, myocardial fibrosis, cardiac senescence, pulmonary hypertension, and diabetic cardiomyopathy by different mechanisms. That shows circRNA advantages and brilliant expectations in the field of CVDs.

中文翻译：

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环状RNA：心血管疾病的新期待


环状RNA（circRNA）是一类5'端和3'端共价连接形成闭环结构的RNA，由特殊的反向剪接方法产生，具有高稳定性、保守序列和组织特异性的特点。目前，已成为研究热点。随着其强大调控功能和作用的发现，circRNA参与和调控生物病理过程的分子机制和未来价值日益显现。其中心血管疾病（CVD）的患病率不断上升。许多研究已经阐明circRNA在CVD的发生和进展中发挥着至关重要的作用。因此，circRNA在CVD领域显示出其优势和美好的期望。在这篇综述中，我们描述了circRNA的生物发生、生物信息学检测和功能，并讨论了circRNA的作用及其对心血管疾病的影响，包括动脉粥样硬化、心肌梗死、心脏肥大和心力衰竭、心肌纤维化、心脏衰老、肺动脉高压和糖尿病不同机制的心肌病。这显示了circRNA在CVD领域的优势和美好期望。