Background. The coronary artery calcium score (CACS) is commonly employed to quantify the degree of calcification in coronary atherosclerosis. Indeed, increased coronary stenosis severity is associated with a progressive increase in CACS. Objectives. This study sought to explore the association between CACS and coronary stenosis of ≥50% and ≥70%. Methods. We conducted a retrospective analysis of patient data collected between July 1, 2017, and March 3, 2022, at Jiangmen Central Hospital. A total of 208 patients, presenting with both symptomatic and asymptomatic manifestations and suspected coronary artery disease (CAD), were included. Statistical analyses included ROC curve assessments, subgroup analyses based on age, and comparisons of CACS values against the presence of coronary stenosis ≥50% and ≥70%. Results. Ultimately, 208 patients were included, with a median age of 65.0 years and a median CACS of 115.7 (interquartile range: 13.7–369.4). A CACS threshold of ≥1300 demonstrated a specificity of 100% for coronary stenosis of ≥50%. Notably, the percentage of patients with obstructive CAD showing CACS = 0 was significantly higher in those under 65 years (15.1%) compared to patients over 65 years (3.8%) (). The inflection point, at which the risk probability for coronary stenosis of ≥50% shifted from being a protective factor to a risk factor, was observed when CACS fell within the range of 63.3 to 66.0. Conclusion. CACS demonstrates good performance for the detection of coronary artery stenosis.

中文翻译：

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冠状动脉钙化评分与冠状动脉狭窄的关系


背景。冠状动脉钙化评分（CACS）通常用于量化冠状动脉粥样硬化的钙化程度。事实上，冠状动脉狭窄严重程度的增加与 CACS 的逐渐增加相关。目标。本研究旨在探讨 CA​​CS 与冠状动脉狭窄≥50% 和≥70% 之间的关联。方法。我们对江门市中心医院2017年7月1日至2022年3月3日期间收集的患者数据进行回顾性分析。共有 208 名患者，既有症状，也有无症状，疑似冠状动脉疾病 (CAD)。统计分析包括 ROC 曲线评估、基于年龄的亚组分析以及 CACS 值与冠状动脉狭窄 ≥50% 和 ≥70% 的比较。结果。最终，纳入了 208 名患者，中位年龄为 65.0 岁，中位 CACS 为 115.7（四分位数范围：13.7-369.4）。 CACS 阈值≥1300 表明冠状动脉狭窄≥50% 的特异性为100%。值得注意的是，与 65 岁以上患者 (3.8%) 相比，65 岁以下患者中显示 CACS = 0 的阻塞性 CAD 患者百分比 (15.1%) 显着更高 ()。当CACS落在63.3至66.0范围内时，观察到冠状动脉狭窄≥50%的风险概率从保护因素转变为危险因素的拐点。结论。 CACS 在检测冠状动脉狭窄方面表现出良好的性能。