Gastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living‑cell‑derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis‑expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets for gastrointestinal cancer. The main features of exosomes and circRNAs are discussed in the present review, along with research on the biological function of exosomal circRNAs in the development and progression of gastrointestinal cancer. It also assesses the advantages and disadvantages of implementing these findings in clinical applications.

中文翻译：

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外泌体circRNA在胃肠道癌症中的作用：在发生、发展、诊断和临床应用中的作用（综述）。


胃肠癌经常在晚期被发现，并且由于缺乏有效和精确的生物标志物和治疗靶点，预后不良。外泌体是源自活细胞的小型囊泡，通过将分子从供体细胞运输到受体细胞，在促进细胞间通讯方面发挥着关键作用。环状RNA（circRNA）在包括胃肠癌在内的多种疾病中错误表达，有望作为胃肠癌的诊断生物标志物和肿瘤治疗靶点。本综述讨论了外泌体和circRNA的主要特征，以及外泌体circRNA在胃肠道癌症发生和进展中的生物学功能的研究。它还评估了在临床应用中实施这些发现的优点和缺点。