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Blood-brain Barrier Permeability May Influence Vasopressor Effects in Anesthetized Patients With Brain Tumor: An Analysis of Magnetic Resonance Imaging Data.
Journal of Neurosurgical Anesthesiology ( IF 3.7 ) Pub Date : 2023-12-08 , DOI: 10.1097/ana.0000000000000948
Mads Rasmussen 1, 2 , Klaus U. Koch 2, 3 , Ulrick S. Espelund 2, 4 , Niwar Mohamad 1 , Anders R. Korshøj 2, 5 , Niels Juul 1 , Hugo Angleys 6 , Lingzhong Meng 7 , Leif Østergaard 6 , Irene K. Mikkelsen 6
Affiliation  

This is a secondary analysis of data from a previous study of anesthetized brain tumor patients receiving ephedrine or phenylephrine infusions. 18 patients with magnetic imaging verified tumor contrast enhancement were included. We hypothesized that vasopressors induce microcirculatory flow changes, characterized by increased capillary transit time heterogeneity (CTH) and decreased mean transit time (MTT), in brain regions exhibiting BBB leakage.

中文翻译:


血脑屏障渗透性可能影响脑肿瘤麻醉患者的血管加压效果:磁共振成像数据分析。



这是对先前接受麻黄碱或去氧肾上腺素输注的麻醉脑肿瘤患者的研究数据的二次分析。 18例经磁成像证实肿瘤对比增强的患者被纳入。我们假设血管升压药会在表现出 BBB 渗漏的大脑区域中引起微循环流量变化,其特征是毛细血管通过时间异质性 (CTH) 增加和平均通过时间 (MTT) 减少。
更新日期:2023-12-08
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