Novel biocompatible and effective hyperthermia (HT) treatment materials for breast cancer therapeutic have recently attracting researchers, because of their effective ablation of cancer cells and negligible damage to healthy cells. Magnetoliposome (MLs) have numerous possibilities for utilize in cancer treatment, including smart drug delivery (SDD) mediated through alternating magnetic fields (AMF). In this work, magnesium ferrite (MgFe₂O₄) encapsulated with liposomes lipid bilayer (MLs), Quercetin (Q)-loaded MgFe₂O₄@Liposomes (Q-MLs) nano-hybrid system were successfully synthesized for magnetic hyperthermia (MHT) and SDD applications. The hybrid system was well-investigated by different techniques using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), Energy dispersive X-ray (EDX), Vibrating sample magnetometer (VSM), Transmission electron microscope (TEM), and Zeta Potential (ZP). The characterization results confirmed the improving quercetin-loading on the MLs surface. TEM analysis indicated the synthesized MgFe₂O₄, MLs, and Q-MLs were spherical with an average size of 23.7, 35.5, and 329.5 nm, respectively. The VSM results revealed that the MgFe₂O₄ exhibit excellent and effective saturation magnetization (M_S) (40.5 emu/g). Quercetin drug loading and entrapment efficiency were found to be equal to 2.1 ± 0.1% and 42.3 ± 2.2%, respectively. The in-vitro Q release from Q-loaded MLs was found 40.2% at pH 5.1 and 69.87% at pH 7.4, verifying the Q-loading pH sensitivity. The MLs and Q-MLs hybrid system as MHT agents exhibit specific absorption rate (SAR) values of 197 and 205 W/g, correspondingly. Furthermore, the Q-MLs cytotoxicity was studied on the MCF-7 breast cancer cell line, and the obtained data demonstrated that the Q-MLs have a high cytotoxicity effect compared to MLs and free Q.

用于乳腺癌治疗的新型生物相容性和有效的热疗（HT）治疗材料最近吸引了研究人员，因为它们可以有效消融癌细胞并且对健康细胞的损害可以忽略不计。磁脂质体 (ML) 在癌症治疗中具有多种用途，包括通过交变磁场 (AMF) 介导的智能药物输送 (SDD)。在这项工作中，成功合成了脂质体脂质双层（MLs）包裹的铁氧体镁_{（MgFe 2} O _{4 ）、}负载槲皮素（Q）的MgFe ₂ O ₄ @脂质体（Q-MLs）纳米杂化系统，用于磁热疗（MHT） ）和 SDD 应用。使用 X 射线衍射 (XRD)、傅里叶变换红外光谱(FT-IR)、能量色散 X 射线 (EDX)、振动样品磁力计 (VSM)、透射电子显微镜 (TEM) 等不同技术对该混合系统进行了深入研究) 和Zeta 电位(ZP)。表征结果证实了 ML 表面槲皮素负载量的提高。TEM分析表明合成的MgFe ₂ O ₄、MLs和Q-MLs呈球形，平均尺寸分​​别为23.7、35.5和329.5 nm。VSM结果表明，MgFe ₂ O ₄表现出优异且有效的饱和磁化强度（M _S）（40.5 emu/g）。槲皮素载药量和包封率分别为 2.1 ± 0.1% 和 42.3 ± 2.2%。负载 Q 的 ML 的体外 Q 释放量在 pH 5.1 时为 40.2%，在 pH 7.4 时为 69.87%，验证了负载 Q 的 pH 敏感性。MLs 和 Q-MLs 混合系统作为 MHT 剂，分别表现出 197 和 205 W/g 的比吸收率 (SAR) 值。此外，在MCF-7乳腺癌细胞系上研究了Q-MLs的细胞毒性，获得的数据表明，与MLs和游离Q相比，Q-MLs具有较高的细胞毒性作用。