Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies,Journal of Enzyme inhibition and Medicinal Chemistry

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Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-12-12 , DOI: 10.1080/14756366.2023.2289007
Zorana Ferjancic ₁ , Filip Bihelovic ₁ , Bojan Vulovic ₁ , Radomir Matovic ₂ , Milena Trmcic ₃ , Aleksandar Jankovic ₂ , Milos Pavlovic ₁ , Filip Djurkovic ₁ , Radivoje Prodanovic ₁ , Aleksandra Djurdjevic Djelmas ₁ , Nevena Kalicanin ₂ , Mario Zlatovic ₁ , Dusan Sladic ₁ , Thomas Vallet ₄ , Marco Vignuzzi _{4,

5} , Radomir N. Saicic _{1,

6}

Affiliation

We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of...

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