Aim

This population-based study aimed to investigate the risk of mental disorders in adults with new-onset type 1 diabetes mellitus compared to the general population without diabetes.

Methods

We selected 10,391 adults with new-onset type 1 diabetes and 51,995 adults in the general population without diabetes with a median follow-up of 7.94 years using the National Health Insurance Database in South Korea between January 2009 and December 2020. The adjusted hazard ratios (aHRs) were estimated for the occurrence of mental disorders.

Results

The incidence of mental disorders was more than twice as high in patients with new-onset type 1 diabetes (66 per 1000 person-years) than in those without diabetes (29 per 1000 person-years). The aHR [95 % confidence interval] comparing adults with new-onset type 1 diabetes with those without diabetes were 2.20 [2.12.2.29] for mental disorders, 3.16 [2.99.3.35], for depression, 2.55 [2.32.2.80] for mood disorders, 1.89 [1.80.1.97] for anxiety and stress related disorders, 2.50 [1.48.4.22] for eating disorders, 2.62 [1.45.4.73] for personality and behavior disorders and 4.39 [3.55.5.43] for alcohol and drug misuse disorders. When new-onset type 1 diabetes occurred at the age of 41 to 50, the aHR of developing mental illness was 2.43 [2.19.2.70], compared to those without diabetes.

Conclusions

In this nationwide prospective study, new-onset type 1 diabetes in adulthood was significantly associated with a higher risk of mental disorders than in the general population without diabetes.

中文翻译：

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19 岁后诊断出的新发 1 型糖尿病成人发生精神障碍的风险增加：一项全国性队列研究

目的

这项基于人群的研究旨在调查与未患糖尿病的一般人群相比，新发 1 型糖尿病成人患精神障碍的风险。

方法

我们使用韩国国家健康保险数据库，在 2009 年 1 月至 2020 年 12 月期间选择了 10,391 名新发 1 型糖尿病成人和 51,995 名非糖尿病普通人群，中位随访时间为 7.94 年。调整后的风险比（ aHRs）用于估计精神障碍的发生率。

结果

新发 1 型糖尿病患者（每 1000 人年 66 例）的精神障碍发生率是非糖尿病患者（每 1000 人年 29 例）的两倍多。比较新发 1 型糖尿病成人与非糖尿病成人的 aHR [95% 置信区间]，精神障碍为 2.20 [2.12.2.29]，抑郁为 3.16 [2.99.3.35]，情绪为 2.55 [2.32.2.80]疾病，焦虑和压力相关疾病为 1.89 [1.80.1.97]，饮食失调为 2.50 [1.48.4.22]，人格和行为障碍为 2.62 [1.45.4.73]，酒精和药物滥用障碍为 4.39 [3.55.5.43]。当新发 1 型糖尿病发生在 41 至 50 岁之间时，与未患糖尿病的人相比，患精神疾病的 aHR 为 2.43 [2.19.2.70]。

结论

在这项全国性的前瞻性研究中，与没有糖尿病的一般人群相比，成年期新发 1 型糖尿病与更高的精神障碍风险显着相关。