A profound comprehension of the intricate regulatory mechanisms within the immune system is essential for navigating the complexities of cancer and immunotherapy. This commentary paper delves into the intricate interplay between tryptophan metabolism, the enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO), and the aryl hydrocarbon receptor (AHR). These elements play pivotal roles in shaping immune responses, particularly in advanced-stage cancers, where their overexpression is associated with poor prognosis and immune suppression [1].

中文翻译：

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AHR 和色氨酸代谢：免疫调节的协同动力学

深入理解免疫系统内复杂的调节机制对于应对癌症和免疫治疗的复杂性至关重要。这篇评论文章深入探讨了色氨酸代谢、吲哚胺 2,3-双加氧酶 1 (IDO1) 和色氨酸双加氧酶 (TDO) 以及芳基烃受体 (AHR) 之间复杂的相互作用。这些元素在形成免疫反应中发挥着关键作用，特别是在晚期癌症中，它们的过度表达与不良预后和免疫抑制有关[1]。