Acne vulgaris is an inflammatory skin condition that affects virtually everyone at some point. Papules, comedones, pustules, scarring, and nodules are standard features of the disease and can have a detrimental social and psychological impact on an individual. Although allopathic acne treatments are available, they have adverse side effects, are expensive, and are prone to cause antibiotic resistance. The present study is aimed at formulating and evaluating topical gels containing Aloe vera, Allium cepa, and Eucalyptus globulus extracts as potential antiacne drugs. Six formulations containing the herbal extracts were prepared using 1% Carbopol 940 as a gelling agent. The phytochemical composition of the plant extracts was determined. The extracts and gels’ minimum inhibitory concentration (MIC) was assessed using the microbroth dilution method. The physicochemical properties of the formulated gels, such as homogeneity, colour, texture, odour, grittiness, spreadability, extrudability, viscosity, pH, and drug content, were evaluated. All the plant extracts contained alkaloids, flavonoids, tannins, triterpenoids, and coumarins. The gel formulations showed varying activity against Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa at various concentrations. The phytochemical components of the plant extracts are probably responsible for the antimicrobial activity of the gel formulations. The 5% Aloe vera-Allium cepa (1 : 1) combination gel formulation showed excellent activity against Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans, with MICs of 12.50, 25.00, 6.25, 25.00, and 12.50 mg/mL, respectively. The gels generally had good physicochemical and antimicrobial properties and could be used as antiacne remedies.

中文翻译：

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草药抗痤疮凝胶制剂的配制和评价

寻常痤疮是一种炎症性皮肤病，几乎每个人都会在某个时候受到影响。丘疹、粉刺、脓疱、疤痕和结节是该疾病的标准特征，可能对个人产生有害的社会和心理影响。尽管可以采用对抗疗法治疗痤疮，但它们具有不良副作用，价格昂贵，并且容易引起抗生素耐药性。本研究旨在配制和评估含有芦荟、洋葱蓝桉提取物作为潜在的抗痤疮药物。使用 1% Carbopol 940 作为胶凝剂制备了六种含有草药提取物的制剂。测定了植物提取物的植物化学成分。使用微肉汤稀释法评估提取物和凝胶的最低抑菌浓度 (MIC)。评估了配制凝胶的理化性质，如均匀性、颜色、质地、气味、砂质、铺展性、挤出性、粘度、pH 值和药物含量。所有植物提取物均含有生物碱、类黄酮、单宁、三萜类化合物和香豆素。凝胶制剂对表皮葡萄球菌、金黄色葡萄球菌、< /span>、，MIC 分别为 12.50、25.00、6.25、25.00 和 12.50mg/mL。该凝胶通常具有良好的理化和抗菌性能，可用作抗痤疮药物。白色念珠菌和铜绿假单胞菌、大肠杆菌金黄色葡萄球菌、表皮葡萄球菌 (1 : 1) 组合凝胶制剂对洋葱-芦荟。植物提取物的植物化学成分可能与凝胶制剂的抗菌活性有关。 5% 不同浓度的铜绿假单胞菌和白色念珠菌、大肠杆菌