Abstract

Early-onset Parkinson’s Disease (EOPD) demands tailored treatments. The younger age of patients might account for a higher sensitivity to transcranial direct current stimulation (tDCS) based non-invasive neuromodulation, which may raise as an integrative therapy in the field. Accordingly, here we assessed the safety and efficacy of the primary left motor cortex (M1) anodal tDCS in EOPD. Ten idiopathic EOPD patients received tDCS at 2.0 mA per 20 min for 10 days within a crossover, double-blind, sham-controlled pilot study. The outcome was evaluated by measuring changes in MDS-UPDRS part III, Non-Motor Symptoms Scale (NMSS), PD-cognitive rating scale, and PD Quality of Life Questionnaire-39 scores. We showed that anodal but not sham tDCS significantly reduced the NMSS total and “item 2” (sleep/fatigue) scores. Other parameters were not modified. No adverse events occurred. M1 anodal tDCS might thus evoke plasticity changes in cortical-subcortical circuits involved in non-motor functions, supporting the value as a therapeutic option in EOPD.

中文翻译：

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运动皮层经颅直流电刺激可改善早发性帕金森病的非运动症状：一项试点研究

摘要

早发性帕金森病 (EOPD) 需要量身定制的治疗方法。患者年龄较小可能导致对基于经颅直流电刺激（tDCS）的非侵入性神经调节的敏感性更高，这可能会作为该领域的综合治疗而提高。因此，我们在这里评估了初级左运动皮层 (M1) 阳极 tDCS 在 EOPD 中的安全性和有效性。在一项交叉、双盲、假对照试点研究中，10 名特发性 EOPD 患者接受了 tDCS，每 20 分钟 2.0 mA，持续 10 天。通过测量 MDS-UPDRS 第三部分、非运动症状量表 (NMSS)、PD 认知评定量表和 PD 生活质量问卷 39 评分的变化来评估结果。我们发现，阳极 tDCS 显着降低了 NMSS 总分和“第 2 项”（睡眠/疲劳）分数，但假 tDCS 没有显着降低。其他参数没有修改。没有发生不良事件。因此，M1 阳极 tDCS 可能会引起涉及非运动功能的皮质-皮质下回路的可塑性变化，支持作为 EOPD 治疗选择的价值。