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CYP-catalysed cycling of clozapine and clozapine-N-oxide promotes the generation of reactive oxygen species in vitro
Xenobiotica ( IF 1.8 ) Pub Date : 2023-12-22 , DOI: 10.1080/00498254.2023.2294473
Ellen Kingston 1 , Malcolm Tingle 1 , Brandi L. Bellissima 1 , Nuala Helsby 2 , Kathryn Burns 1
Affiliation  

Clozapine is an effective atypical antipsychotic indicated for treatment-resistant schizophrenia, but is under-prescribed due to the risk of severe adverse drug reactions such as myocarditis.A mech...

中文翻译:

CYP 催化的氯氮平和氯氮平-N-氧化物循环促进体外活性氧的产生

氯氮平是一种有效的非典型抗精神病药,适用于治疗难治性精神分裂症,但由于存在严重药物不良反应(如心肌炎)的风险,处方不足。
更新日期:2023-12-22
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