Control of mosquitoes is considered an essential public health priority. This study was designed to estimate the larvicidal activity of two formulations of Cinnamomum zeylanicum EO for controlling Culex pipiens larvae. The prepared formulations were a nanoemulsion of cinnamon (CNE), cinnamon (CN) alone and ordinary cinnamon essential oil mixed with sesame oil (CSO). The cinnamon + sesame oil (CSO) was added as one part cinnamon to 3 parts SO. Different concentrations were prepared and applied following the WHO larvicidal bioassay protocol. Our findings revealed that the LC50 of the CNE form ranged from 85.3 µg/mL to 28.30 µg/mL. The LC50 of SO alone was 1265 µg/mL but when mixed with CNE to form the CSO mixture, this decreased to 159.00 µg/mL. In terms of residual effect, the ordinary form of cinnamon had a residual effect in water for 72 h at a dose of 1000 µg/ml, but this extended to 120 h at the same dose when the CNE form was used. However CSO did not have a residual effect, however. The nanoemulsion form significantly improved the efficacy and residual effect of cinnamon against Culex pipiens larvae. Additionally, mixing cinnamon with sesame oil had a synergistic effect. This may assist control strategies against the house mosquito, Culex pipiens.

中文翻译：

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肉桂油制剂的合成、功效及其对普通家蚊幼虫的可持续释放

控制蚊子被认为是重要的公共卫生优先事项。本研究旨在评估两种锡兰肉桂 EO 制剂用于控制淡色库蚊幼虫的杀幼虫活性。制备的配方是肉桂纳米乳液（CNE）、单独的肉桂（CN）以及与芝麻油混合的普通肉桂精油（CSO）。将肉桂+芝麻油(CSO)作为一份肉桂添加到3份SO中。按照世界卫生组织杀幼虫生物测定方案制备和应用不同浓度。我们的研究结果显示，CNE 形式的 LC50 范围为 85.3 µg/mL 至 28.30 µg/mL。 SO 单独的 LC50 为 1265 µg/mL，但与 CNE 混合形成 CSO 混合物时，LC50 降至 159.00 µg/mL。就残留效果而言，普通形式的肉桂在剂量为1000μg/ml的情况下在水中具有72小时的残留效果，但当使用CNE形式时，在相同剂量下该残留效果延长至120小时。然而，CSO 并没有产生残余效应。纳米乳剂形式显着提高了肉桂对淡色库蚊幼虫的功效和残留效果。此外，将肉桂与芝麻油混合具有协同作用。这可能有助于针对家蚊（Culex pipiens）的控制策略。