Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA—which is frequently mutated in gastric cancer—appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling , Schaefer et al. take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes.

中文翻译：

---

RHOA 司机在胃癌中采取替代路线

致癌性小鸟苷三磷酸酶 (GTPase) 的特征通常是一组有限的激活突变，这些突变会影响其内在生化功能，但 RHOA（在胃癌中经常发生突变）似乎没有阅读说明书。之前已经描述了胃癌中的 Y42C RHOA 突变，本期科学信号,谢弗等人。研究稍微不太常见的 L57V 突变，发现单个 RHOA 突变可能会产生不同且不可预测的信号结果。