Interventricular septal flattening, frequently present in pulmonary hypertension (PH) can be quantified by the left ventricular eccentricity index (EI) measured at end-diastole (EId), end-systole (EIs) and at maximal septal flattening (EIm). In humans, EI correlates with invasive pulmonary arterial pressure. Left ventricular eccentricity indices were retrospectively measured in four groups (no, mild, moderate and severe PH) with interpretable tricuspid and/or pulmonary regurgitation. Ninety-seven dogs were included, with no (n = 29), mild (n = 13), moderate (n = 25) and severe (n = 30) PH. The intra- and inter-observer variability for EI measurements ranged from 2 % to 11 %. All EI were significantly elevated in severe compared to no, mild and moderate PH (P < 0.0005). In the moderate group, EIs and EIm were higher compared to the no PH group (P < 0.01). Tricuspid and pulmonary regurgitation pressure gradients and RHR parameters correlated with EId, EIs and EIm in all groups. Optimal cut-off values discriminating moderate and severe PH from no and mild PH were 1.24 (Sensitivity (Se) 60 %; Specificity (Sp) 90 %) for EId, 1.34 (Se 67 %; Sp 95 %) for EIs and 1.37 (Se 76 %; Sp 83 %) for EIm. Left ventricular eccentricity indices are reproducible echocardiographic variables increasing with severity of PH. Dogs with moderate and severe PH can be discriminated from dogs with no or mild PH using EIs and EIm.

中文翻译：

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左心室偏心指数评估犬毛细血管前肺动脉高压

肺动脉高压（PH）中常见的室间隔扁平化可以通过在舒张末期（EId）、收缩末期（EIs）和最大室间隔扁平化（EIm）时测量的左心室偏心指数（EI）来量化。在人类中，EI 与侵入性肺动脉压相关。回顾性测量四组（无、轻度、中度和重度 PH）的左心室偏心率指数，并可解释三尖瓣和/或肺动脉瓣反流。共有 97 只狗参与其中，其中没有 (n = 29)、轻度 (n = 13)、中度 (n = 25) 和重度 (n = 30) PH。 EI 测量的观察者内部和观察者之间的变异性范围为 2% 至 11%。与无PH、轻度PH和中度PH相比，重度PH的所有EI均显着升高（P<0.0005）。中度组的 EIs 和 EIm 高于无 PH 组（P < 0.01）。所有组中三尖瓣和肺动脉瓣反流压力梯度以及 RHR 参数与 EId、EIs 和 EIm 相关。区分中度和重度 PH 与无和轻度 PH 的最佳截止值对于 EId 为 1.24（敏感性 (Se) 60%；特异性 (Sp) 90%），对于 EI 为 1.34（Se 67%；Sp 95%），对于 EI 为 1.37（敏感性 (Se) 60%；特异性 (Sp) 90%）。对于 EIm，Se 76%；Sp 83%）。左心室偏心率指数是可重复的超声心动图变量，随着 PH 的严重程度而增加。使用 EI 和 EIm 可以将患有中度和重度 PH 的狗与没有或轻度 PH 的狗区分开来。